| Date | Weekday | Event |
| May 19, 1536 | Tuesday | Anne Boleyn Executed |
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| May 19, 1749 | Monday | George II grants charter to Ohio Company to settle Ohio Valley |
| May 19, 1780 | Friday | About midday - near-total darkness descends on much of New England |
| May 19, 1856 | Monday | Sen Charles Sumner - Mass - spoke out against proslavery people |
| May 19, 1862 | Monday | Homestead Act becomes law |
| May 19, 1898 | Thursday | Simplon Tunnel opens from Brig - Switzerland to Iselle - Italy |
| May 19, 1971 | Wednesday | USSR Mars 2 launched 1st spacecraft to crash land on Mars |